M. Sebastien Roger

Enseignant-Chercheur (MCU) en Physiologie (section CNU66) Enseignements: - L2 Nerfs - Muscles (TP) - L3 Métabolisme hépatique (TP) - M1 Physiologie Neurosensorielle (CM et TD) co-Responsable avec C. Belzung - M1 Physiologie humaine (CM, TD et TP) Resonsable - M1 Biologie de la cellule épithéliale normale et pathologique (CM, TD, TP) co-Responsable avec F. Esnard - M2 Signalisation cellulaire et moléculaire (CM)

Département de physiologie animale
UFR de Sciences et Techniques
UFR de Médecine

Coordonnées

Tél: 0247366130
Mail: sebastien.roger@univ-tours.fr
Site internet: http://www.n2c.univ-tours.fr/

Discipline(s)

Physiologie

Thèmes de recherche

Expression et fonctionnalité de canaux ioniques (canaux sodiques NaV et récepteurs purinergiques P2X) dans des cellules cancéreuses d'origine épithéliale (cellules mammaires). Rôles dans les phénomènes de migration et d'invasivité. Régulation de ces canaux par des acides gras polyinsaturés à longue chaîne d'origine alimentaire.

Activités / CV

PUBLICATIONS RECENTES / RECENT PUBLICATIONS

ROGER S. #, GILLET L., Baroja-Mazo A., SURPRENANT A. & PELEGRIN P. A C-terminal calmodulin binding motif differentially controls human and rat P2X7 receptor current facilitation. J. Biol Chem, 2010

GILLET L., ROGER S., BOUGNOUX P., LE GUENNEC J.-Y. & BESSON P. Beneficial effects of omega-3 long-chain fatty acids in breast cancer and cardiovascular diseases: voltage-gated sodium channels as a common feature? Biochimie. 2010

ROGER S. #, MEI Z.Z, BALDWIN J., BRADLEY H., DONG L., BALDWIN S.A., SURPRENANT A. & JIANG L.-H. Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions. Journal of Psychiatric Research. 2010 Apr;44(6):347-55. Epub 2009 Nov 2009)

GILLET L*., ROGER S*., BESSON P., LECAILLE F., GORE J., BOUGNOUX P., LALMANACH G. & LE GUENNEC J-Y.
Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J. Biol Chem, 2009 Mar 27;284(13):8680-91. Epub 2009 Jan 28
*Both authors contributed equally to the work

TRAN TA., GILLET L., ROGER S., BESSON P., WHITE E. & LE GUENNEC J-Y.
Non anti-mitotic concentrations of taxol reduce breast cancer cell invasiveness. Biochemical and Biophysical Research Communications, 2009, 379:304-308.
ROGER S., PELEGRIN P. & SURPRENANT A.

Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding. J Neurosci, 2008; 28 (25): 6393-6401.

LIU X., SURPRENANT A., MAO H.-J., ROGER S., XIA R., BRADLEY H. & JIANG L.-H.

Identification of key residues coordinating functional inhibition of P2X7 receptors by zinc and copper. Mol Pharmacol, 2008;73(1):252-9. Epub 2007 Oct 24.

ROGER S., ROLLIN J., BARASCU A., BESSON P., RAYNAL P.-Y., IOCHMANN S., LEI M., BOUGNOUX P., GRUEL Y. & LE GUENNEC J.-Y.
Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines. Int J Biochem Cell Biol, 2007; 39(4):774-86. Epub 2007 Jan 20.

TRAN T.-A., ROGER S., LE GUENNEC J.-Y., TRANQUART F. & BOUAKAZ A.

Effect of ultrasound-activated microbubbles on the cell electrophysiological properties. Ultrasound Med Biol, 2007, 33(1), 158-163.

POTIER M., JOULIN V., ROGER S., BESSON P., JOURDAN M.-L., LE GUENNEC J.-Y., BOUGNOUX P. & VANDIER C.

Identification of SK3 channel as a new mediator of breast cancer cell migration. Mol Cancer Ther, 2006, 5(11), 2946-2953.

ROGER S., POTIER M., VANDIER C, BESSON P & LE GUENNEC J.-Y.

Voltage-gated sodium channels : New targets in cancer therapy. Review in Curr Pharm Design, 2006, 12 (28) : 3681-3695.

LAUMONIER F., ROGER S., GUERIN P., MOLINARI F., M'RAD R., BELHADJ A., HALAYEM M., PERSICO A.M., CAHARD D., HOLBERT S., ANDRES C., CHAABOUNI H., COLLEAUX L., CONSTANT J., LE GUENNEC J.-Y., MORAINE C., & BRIAULT S.

Disruption of the large conductance Ca2+-activated K+ channel gene (KCNMA1) is associated with autistic disorder. Am J Psychatry, 2006, 163(9) : 1622-1629.

JUDE S., ROGER S., MARTEL E., BESSON P., RICHARD S., BOUGNOUX P., CHAMPEROUX P. & LE GUENNEC J.-Y.

Dietary long-chain omega-3 fatty acids: a comparison of their protective effects on coronary heart disease and breast cancers. Review in Prog Biophys Mol Biol, 2006, 90 : 299-325. Epub 2005 Jun 15.

ROGER S., POTIER M., VANDIER C, LE GUENNEC J.-Y. & BESSON P.

Description and role in proliferation of iberiotoxin-sensitive currents in different human mammary epithelial normal and cancerous cells. BBA-Biomembranes, 2004, 1667 : 190-199.

ROGER S., LE GUENNEC J.-Y. & BESSON P.

Particular sensitivity to calcium channel blockers of the fast inward voltage-dependant sodium current involved in the invasive properties of a metastatic breast cancer cell line. Br J Pharmacol, 2004,141: 610-615.

ROGER S., BESSON P. & LE GUENNEC J.-Y.

Influence of the whole-cell patch-clamp configuration on electrophysiological properties of the voltage-dependent sodium current expressed in MDA-MB-231 breast cancer cells. Eur Biophys J , 2004, 33: 274-279.

ROGER S., BESSON P. & LE GUENNEC J.-Y.

Involvement of a novel fast inward sodium current in the invasion capacity of a breast cancer cell line. BBA-Biomembranes, 2003, 1616 (2): 107-111.

JUDÉ S., BEDUT S., ROGER S., PINEAU M., CHAMPEROUX P., WHITE E., LE GUENNEC J-Y. Peroxidation of docosahexaenoic acid is responsible of its effects on potassium currents in rat ventricular myocytes. Br J Pharmacol, 2003, 139 : 816-822.

CURRICULUM VITAE

Depuis Septembre 2007 : Maître de Conférences Universitaire (Lecturer in Physiology)- Université de Tours- Inserm U921.

Avr. - Aout 2007: Post-doctoral Research associate - University of Manchester, UK

Fev. 2006- Mars 2007 : Post-doctoral Research associate - University of Sheffield, UK

2002-2005: Doctorat en Sciences de la vie (PhD in Life Sciences). Université de Tours - Inserm E0211.

2001-2002: DEA Signalisation et interactions cellulaires et moléculaires (Master degree in Cell Signalling)- Université de Tours.